Publications

2021

Maternal Immune Activation during Pregnancy Alters Postnatal Brain Growth and Cognitive Development in Nonhuman Primate Offspring

Vlasova RM, Iosif AM, Ryan AM, Funk LH, Murai T, Chen S, Lesh TA, Rowland DJ, Bennett J, Hogrefe CE, Maddock RJ, Gandal MJ, Geschwind DH, Schumann CM, Van de Water J, McAllister AK, Carter CS, Styner MA, Amaral DG, Bauman MD. Maternal Immune Activation during Pregnancy Alters Postnatal Brain Growth and Cognitive Development in Nonhuman Primate Offspring. J Neurosci. 2021 Dec 1;41(48):9971-9987. doi: 10.1523/JNEUROSCI.0378-21.2021. Epub 2021 Oct 4. PMID: 34607967; PMCID: PMC8638691.

Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors

Krebs MD, Themudo GE, Benros ME, Mors O, Børglum AD, Hougaard D, Mortensen PB, Nordentoft M, Gandal MJ, Fan CC, Geschwind DH, Schork AJ, Werge T, Thompson WK. Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors. Nat Commun. 2021 Nov 16;12(1):6617. doi: 10.1038/s41467-021-26903-7. PMID: 34785645; PMCID: PMC8595374.

Three decades of ASD genetics: building a foundation for neurobiological understanding and treatment

Eyring KW, Geschwind DH. Three decades of ASD genetics: building a foundation for neurobiological understanding and treatment. Hum Mol Genet. 2021 Oct 1;30(20):R236-R244. doi: 10.1093/hmg/ddab176. PMID: 34313757; PMCID: PMC8861370.

Oxytocin for Autism Spectrum Disorder – Down, but Not Out

Geschwind DH. Oxytocin for Autism Spectrum Disorder – Down, but Not Out. N Engl J Med. 2021 Oct 14;385(16):1524-1525. doi: 10.1056/NEJMe2110158. PMID: 34644477.

Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis

Allison T, Langerman J, Sabri S, Otero-Garcia M, Lund A, Huang J, Wei X, Samarasinghe RA, Polioudakis D, Mody I, Cobos I, Novitch BG, Geschwind DH, Plath K, Lowry WE. Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis. Stem Cell Reports. 2021 Oct 12;16(10):2548-2564. doi: 10.1016/j.stemcr.2021.08.006. Epub 2021 Sep 9. PMID: 34506726; PMCID: PMC8514853.

Cell type hierarchy reconstruction via reconciliation of multi-resolution cluster tree

Peng M, Wamsley B, Elkins AG, Geschwind DH, Wei Y, Roeder K. Cell type hierarchy reconstruction via reconciliation of multi-resolution cluster tree. Nucleic Acids Res. 2021 Sep 20;49(16):e91. doi: 10.1093/nar/gkab481. PMID: 34125905; PMCID: PMC8450107.

Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications

López-Aranda MF, Chattopadhyay I, Boxx GM, Fraley ER, Silva TK, Zhou M, Phan M, Herrera I, Taloma S, Mandanas R, Bach K, Gandal M, Geschwind DH, Cheng G, Rzhetsky A, White SA, Silva AJ. Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications. Sci Adv. 2021 Sep 17;7(38):eabf2073. doi: 10.1126/sciadv.abf2073. Epub 2021 Sep 17. PMID: 34533985; PMCID: PMC8448451.

Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis

Aygün N, Elwell AL, Liang D, Lafferty MJ, Cheek KE, Courtney KP, Mory J, Hadden-Ford E, Krupa O, de la Torre-Ubieta L, Geschwind DH, Love MI, Stein JL. Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis. Am J Hum Genet. 2021 Sep 2;108(9):1647-1668. doi: 10.1016/j.ajhg.2021.07.011. Epub 2021 Aug 19. PMID: 34416157; PMCID: PMC8456186.

Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome

Saravanapandian V, Nadkarni D, Hsu SH, Hussain SA, Maski K, Golshani P, Colwell CS, Balasubramanian S, Dixon A, Geschwind DH, Jeste SS. Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome. Mol Autism. 2021 Aug 3;12(1):54. doi: 10.1186/s13229-021-00460-8. PMID: 34344470; PMCID: PMC8336244.

DIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease

Kundishora AJ, Peters ST, Pinard A, Duran D, Panchagnula S, Barak T, Miyagishima DF, Dong W, Smith H, Ocken J, Dunbar A, Nelson-Williams C, Haider S, Walker RL, Li B, Zhao H, Thumkeo D, Marlier A, Duy PQ, Diab NS, Reeves BC, Robert SM, Sujijantarat N, Stratman AN, Chen YH, Zhao S, Roszko I, Lu Q, Zhang B, Mane S, Castaldi C, López-Giráldez F, Knight JR, Bamshad MJ, Nickerson DA, Geschwind DH, Chen SL, Storm PB, Diluna ML, Matouk CC, Orbach DB, Alper SL, Smith ER, Lifton RP, Gunel M, Milewicz DM, Jin SC, Kahle KT. DIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease. JAMA Neurol. 2021 Aug 1;78(8):993-1003. doi: 10.1001/jamaneurol.2021.1681. PMID: 34125151; PMCID: PMC8204259.