Publications

2021

A neurogenetic analysis of female autism

Jack A, Sullivan CAW, Aylward E, Bookheimer SY, Dapretto M, Gaab N, Van Horn JD, Eilbott J, Jacokes Z, Torgerson CM, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Gupta AR; GENDAAR Consortium. A neurogenetic analysis of female autism. Brain. 2021 Jul 28;144(6):1911-1926. doi: 10.1093/brain/awab064. PMID: 33860292; PMCID: PMC8320285.

Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility

Hartl CL, Ramaswami G, Pembroke WG, Muller S, Pintacuda G, Saha A, Parsana P, Battle A, Lage K, Geschwind DH. Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility. Nat Neurosci. 2021 Sep;24(9):1313-1323. doi: 10.1038/s41593-021-00887-5. Epub 2021 Jul 22. PMID: 34294919; PMCID: PMC10263365.

C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation

Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, Vazquez M, Kim J, Ghaffari L, O’Rourke JG, Geschwind DH, Blurton-Jones M, Holtzman DM, Sattler R, Baloh RH. C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation. Neuron. 2021 Jul 21;109(14):2275-2291.e8. doi: 10.1016/j.neuron.2021.05.020. Epub 2021 Jun 15. PMID: 34133945; PMCID: PMC8298293.

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y. Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. Nat Commun. 2021 Jun 25;12(1):3958. doi: 10.1038/s41467-021-24232-3. PMID: 34172753; PMCID: PMC8233314.

Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders

Hu B, Won H, Mah W, Park RB, Kassim B, Spiess K, Kozlenkov A, Crowley CA, Pochareddy S; PsychENCODE Consortium; Li Y, Dracheva S, Sestan N, Akbarian S, Geschwind DH. Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders. Nat Commun. 2021 Jun 25;12(1):3968. doi: 10.1038/s41467-021-24243-0. PMID: 34172755; PMCID: PMC8233376.

Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation

Liang D, Elwell AL, Aygün N, Krupa O, Wolter JM, Kyere FA, Lafferty MJ, Cheek KE, Courtney KP, Yusupova M, Garrett ME, Ashley-Koch A, Crawford GE, Love MI, de la Torre-Ubieta L, Geschwind DH, Stein JL. Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation. Nat Neurosci. 2021 Jul;24(7):941-953. doi: 10.1038/s41593-021-00858-w. Epub 2021 May 20. PMID: 34017130; PMCID: PMC8254789.

Transcriptomic networks implicate neuronal energetic abnormalities in three mouse models harboring autism and schizophrenia-associated mutations

Gordon A, Forsingdal A, Klewe IV, Nielsen J, Didriksen M, Werge T, Geschwind DH. Transcriptomic networks implicate neuronal energetic abnormalities in three mouse models harboring autism and schizophrenia-associated mutations. Mol Psychiatry. 2021 May;26(5):1520-1534. doi: 10.1038/s41380-019-0576-0. Epub 2019 Nov 8. PMID: 31705054.

Alterations in Retrotransposition, Synaptic Connectivity, and Myelination Implicated by Transcriptomic Changes Following Maternal Immune Activation in Nonhuman Primates

Page NF, Gandal MJ, Estes ML, Cameron S, Buth J, Parhami S, Ramaswami G, Murray K, Amaral DG, Van de Water JA, Schumann CM, Carter CS, Bauman MD, McAllister AK, Geschwind DH. Alterations in Retrotransposition, Synaptic Connectivity, and Myelination Implicated by Transcriptomic Changes Following Maternal Immune Activation in Nonhuman Primates. Biol Psychiatry. 2021 May 1;89(9):896-910. doi: 10.1016/j.biopsych.2020.10.016. Epub 2020 Nov 2. PMID: 33386132; PMCID: PMC8052273.

Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors

Chang TS, Ding Y, Freund MK, Johnson R, Schwarz T, Yabu JM, Hazlett C, Chiang JN, Wulf DA; UCLA Precision Health Data Discovery Repository Working Group; Geschwind DH, Butte MJ, Pasaniuc B. Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors. iScience. 2021 Mar 19;24(3):102188. doi: 10.1016/j.isci.2021.102188. Epub 2021 Feb 12. PMID: 33615196; PMCID: PMC7879099.

Gene co-expression network analysis in human spinal cord highlights mechanisms underlying amyotrophic lateral sclerosis susceptibility

Wang JC, Ramaswami G, Geschwind DH. Gene co-expression network analysis in human spinal cord highlights mechanisms underlying amyotrophic lateral sclerosis susceptibility. Sci Rep. 2021 Mar 11;11(1):5748. doi: 10.1038/s41598-021-85061-4. PMID: 33707641; PMCID: PMC7970949.