Jiani "Jenny" Yin

Jiani is a post-doctoral fellow who is working on understanding how 3D chromatin structure impacts gene regulation and disease susceptibility in autism and in dementia. Her research in the Geschwind lab mainly focuses on generating 3D maps of the genome from postmortem brain samples of individuals with autism and those who were unaffected, across different age groups. We hypothesize that by comparing ASD 3D genomes to neurotypical ones, we will identify genomic conformational signatures of ASD, and understand how common genetic variants exert effects on regions that interact with them. Similarly, she is exploring changes in 3D chromatin at a major risk locus for dementia, the MAPT locus on chromosome 17q21 as part of the Tau Center without Walls with the labs of Alison Goate and Martin Kampman.