We are proud to announce the publication of many years of work by the PsychENCODE consortium, which includes 9 papers in Science (https://lnkd.in/gsqKeenW). PsychENCODE is focused on elucidating the genetic and molecular mechanisms that underlie susceptibility for a broad range of neuropsychiatric conditions, ranging from autism to PTSD and schizophrenia. Several of these papers also provide basic gene regulatory maps during human brain development for decoding disease risk at unprecedented resolution. Explore the collection here: https://lnkd.in/g5vh4VSa.
We want to highlight the work of Brie Wamsley and others from the Geschwind lab for their work in autism that is one of the core papers in this collection (https://lnkd.in/gTj8pFHE). Wamsley et al. integrate single cell transcriptomics with chromatin accessibility to define regulatory networks that are poised to drive changes observed in the brains of autistic individuals, providing a roadmap for connecting genetic susceptibility to molecular pathways and cells in brain. Also, please see the collaborative work led by Preshant Emani and his colleagues from the Gerstein lab that provides an integrated single cell, population-level resource and deep-learning models for understanding gene regulation at the single cell level in adult brain (https://lnkd.in/gVrfcWZh).